Christophe Benoist, Harvard Medical School, USA

Christophe Benoist

Christophe Benoist is a molecular immunologist, currently the Morton Grove-Ramussen Professor of Immuno-hematology at Harvard Medical School.

He initially trained in France, obtaining an M.D. from the Université de Paris – Bichat/Beaujon and a Ph.D. with P. Chambon at the Université Louis Pasteur, Strasbourg, followed by postdoctoral studies at Stanford University. He returned to France in 1983 to establish an Immunology research laboratory at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, in conjunction with Dr. Diane Mathis. In 1999 the lab moved to Harvard Medical School, first at the Joslin Diabetes Center, then in the Division of Immunology at the HMS Department of Microbiology and Immunobiology. He is also an Associate Faculty Member of The Broad Institute, and Affiliated Faculty of the Harvard Stem Cell Institute. He plays a leadership role in the Immunological Genome Project consortium. Dr. Benoist was elected to the French Académie des Sciences in 1999, and to the US National Academy of Sciences in 2005.

The Benoist/Mathis lab works in the fields of T cell tolerance and autoimmunity, attempting to decipher the molecular and cellular mechanisms that control T cell differentiation, the acquisition and maintenance of immunological tolerance or its failure in autoimmune diseases. The lab has historically used germline modification tools to generate important mouse models of tolerance and autoimmunity. Current investigations involve a broad range of Systems Immunology approaches to decipher immunoregulation in mice and humans, the microbiome’s influence on these processes, and the effect of therapeutic immunomodulators.

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